Hydrophilic-hydrophilic mixed micellar system: effect on solubilization of drug

Anionic-nonionic surfactants coupled micellar thin-layer chromatography: synergistic effect on simultaneous separation of hydrophilic vitamins.

A micellar thin-layer chromatographic system comprising of silica layer impregnated with 0.01% sodium dodecyl sulphate (SDS) as stationary phase and 0.1% aqueous solution of Cween 80 as mobile phase was identified as the most favorable system for the mutual separation of five water-soluble vitamins (folic acid, cyanocobalamin, thiamine, pyridoxine, and riboflavin). Effects of the presence of me...

Modulation of drug release from hydrophilic matrices

Hydrophilic Matrices for Oral Control Drug Delivery

Oral controlled drug delivery has gathered tremendous attention over the years due to its many advantages over conventional dosage forms. Polymer-based matrices have become an integral part of the pharmaceutical industry. Hydrophilic matrices are capable of controlling the release of drug over an extended period of time. Hydrophilic polymers, especially the hydrophilic derivatives of cellulose ...

Effect of a Clathrate-Forming Counterion on Micellar Solubilization

Clathrate hydrates are supramolecular solids in which small, hydrophobic species are trapped inside a network of hydrogen-bonded water cages. While the best known examples are the natural gas hydrates, similar crystalline structures can also be formed from salts of tetra-n-butylammonium hydroxide (TBAOH). When TBAOH is reacted with medium to long chain carboxylic acids it produces surfactant co...

Effect of medium pH on the cytotoxicity of hydrophilic statins.

PURPOSE The aim of this study was to examine the mechanism of pravastatin- and rosuvastatin-induced cytotoxicity and the relationship between pravastatin- and rosuvastatin-induced cytotoxicity and medium pH using human prototypic embryonal rhabdomyosarcoma cell line (RD) and rat myoblast cell line (L6) as a model of in vitro skeletal muscle. METHODS Statin-induced reduction of cell viability ...